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https://hdl.handle.net/10356/104965
Title: | Dynamics and stability of polymorphic human telomeric G-quadruplex under tension | Authors: | Efremov, Artem K. Phan, Anh Tuân Yan, Jie You, Huijuan Zeng, Xiangjun Xu, Yue Lim, Ci Ji |
Keywords: | DRNTU::Science::Physics::Geophysics and geomagnetism | Issue Date: | 2014 | Source: | You, H., Zeng, X., Xu, Y., Lim, C. J., Efremov, A. K., Phan, A. T., et al. (2014). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research, 42(13), 8789-8795. | Series/Report no.: | Nucleic acids research | Abstract: | As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K+ concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified. | URI: | https://hdl.handle.net/10356/104965 http://hdl.handle.net/10220/20391 |
ISSN: | 0305-1048 | DOI: | 10.1093/nar/gku581 | Schools: | School of Physical and Mathematical Sciences | Rights: | © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SPMS Journal Articles |
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Nucl. Acids Res.-2014-You-8789-95.pdf | 1.31 MB | Adobe PDF | View/Open |
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