dc.contributor.authorDing, Feiqing
dc.contributor.authorLeow, Min Li
dc.contributor.authorMa, Jimei
dc.contributor.authorWilliam, Ronny
dc.contributor.authorLiao, Hongze
dc.contributor.authorLiu, Xue-Wei
dc.date.accessioned2014-09-08T07:59:03Z
dc.date.available2014-09-08T07:59:03Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationDing, F., Leow, M. L., Ma, J., William, R., Liao, H., & Liu, X.-W. (2014). Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities. Chemistry - An Asian journal, 9(9), 2548-2554.en_US
dc.identifier.issn1861-4728en_US
dc.identifier.urihttp://hdl.handle.net/10220/20459
dc.description.abstractA collective synthesis of 4-hydroxy-2-pyridone alkaloids—specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C—has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki–Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μm. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesChemistry - An Asian journalen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Chemistry
dc.titleCollective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activitiesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/asia.201402466


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