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Title: Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups
Authors: Tan, Si Yu
Ang, Chung Yen
Li, Peizhou
Yap, Qi Ming
Zhao, Yanli
Keywords: DRNTU::Science::Chemistry
Issue Date: 2014
Source: Tan, S. Y., Ang, C. Y., Li, P., Yap, Q. M., & Zhao, Y. (2014). Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups. Chemistry - A European Journal, 20(36), 11276-11282.
Series/Report no.: Chemistry - a European journal
Abstract: Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery.
ISSN: 0947-6539
DOI: 10.1002/chem.201403551
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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