dc.contributor.authorHu, Benhui
dc.contributor.authorShi, Wenxiong
dc.contributor.authorWu, Yun-Long
dc.contributor.authorLeow, Wan Ru
dc.contributor.authorCai, Pingqiang
dc.contributor.authorLi, Shuzhou
dc.contributor.authorChen, Xiaodong
dc.date.accessioned2014-09-10T07:43:24Z
dc.date.available2014-09-10T07:43:24Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationHu, B., Shi, W., Wu, Y.-L., Leow, W. R., Cai, P., Li, S., et al. (2014). Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology. Advanced Materials, 26(33), 5786-5793.en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttp://hdl.handle.net/10220/20499
dc.description.abstractProgrammable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAdvanced materialsen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Engineering::Materials
dc.titleOrthogonally engineering matrix topography and rigidity to regulate multicellular morphologyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1002/adma.201402489


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