Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice
Maji, Swarup Kumar
Yu, Sidney Wing-Kwong
Date of Issue2014
School of Physical and Mathematical Sciences
An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.