dc.contributor.authorManavalan, Arulmani
dc.contributor.authorRamachandran, Umamaheswari
dc.contributor.authorSundaramurthi, Husvinee
dc.contributor.authorMishra, Manisha
dc.contributor.authorSze, Siu Kwan
dc.contributor.authorHu, Jiang-Miao
dc.contributor.authorFeng, Zhi Wei
dc.contributor.authorHeese, Klaus
dc.identifier.citationManavalan, A., Ramachandran, U., Sundaramurthi, H., Mishra, M., Sze, S. K., Hu, J.-M., et al. (2012). Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. International journal of biochemistry and molecular biology, 3(2), 219-241.en_US
dc.description.abstractTianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions of tianma thus led us to investigate its specific effects on neuronal signalling. Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach. We identified 2178 proteins, out of which 74 were found to be altered upon tianma treatment in differentiated mouse neuronal N2a cells. Based on the observed data obtained, we hypothesize that tianma could promote neuro-regenerative processes by inhibiting stress-related proteins and mobilizing neuroprotective genes such as Nxn, Dbnl, Mobkl3, Clic4, Mki67 and Bax with various regenerative modalities and capacities related to neuro-synaptic plasticity.en_US
dc.relation.ispartofseriesInternational journal of biochemistry and molecular biologyen_US
dc.rights© 2012 e-Century Publishing. This paper was published in International Journal of Biochemistry and Molecular Biology and is made available as an electronic reprint (preprint) with permission of e-Century Publishing. The paper can be found at the following official URL: http://www.ijbmb.org/1205001A.html.  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectDRNTU::Science::Biological sciences::Biochemistry
dc.titleGastrodia elata Blume (tianma) mobilizes neuro-protective capacitiesen_US
dc.typeJournal Article
dc.contributor.researchInstitute of Advanced Studiesen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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