dc.contributor.authorLiang, Willmann
dc.contributor.authorTeong, Ivy Wen Jia
dc.contributor.authorKoon, Johnny Chi Man
dc.contributor.authorLau, Clara Bik San
dc.contributor.authorFung, Kwok Pui
dc.contributor.authorLeung, Ping Chung
dc.identifier.citationLiang, W., Teong, I. W. J., Koon, J. C. M., Lau, C. B. S., Fung, K. P., & Leung, P. C. (2012). Inhibitory effects of salviae miltiorrhizae radix (danshen) and puerariae lobatae radix (gegen) in carbachol-induced rat detrusor smooth muscle contractility. International journal of physiology, pathophysiology and pharmacology, 4(1), 36-44.en_US
dc.description.abstractBoth danshen (D) and gegen (G) have proven relaxant effects on vascular smooth muscle, thus their potential bladder inhibitory effects have impending interests in urology. The aim of this study was to demonstrate the novel effects of D and G on detrusor smooth muscle contractility. Urothelium-intact (+UE) and urothelium-denuded (–UE) detrusor strips were isolated from the rat. Isometric tension was measured using a myograph system. Carbachol (CCh) was used to pre-contract the detrusor strips prior to stepwise relaxation by adding extracts of D, G, and a DG (7:3) formulation. Tonic relaxation level and phasic contractile activity under the herbal treatments were analyzed. There was no difference in the herbal effects between +UE and –UE strips. D alone induced a much smaller relaxation than G alone or DG. G alone also suppressed phasic amplitude but not phasic frequency while DG suppressed both parameters. D and G acted synergistically to yield the observed effects on detrusor smooth muscle. The findings showed that the DG formulation were able to relax the detrusor as well as suppress phasic contractions, both actions important in maintaining normal bladder filling and urine storage processes. Hence DG may have new application in the management of bladder disorders.en_US
dc.format.extent9 p.en_US
dc.relation.ispartofseriesInternational journal of physiology, pathophysiology and pharmacologyen_US
dc.rights© 2012 e-Century Publishing. This paper was published in International Journal of Physiology, Pathophysiology and Pharmacology and is made available as an electronic reprint (preprint) with permission of e-Century Publishing. The paper can be found at the following official URL: http://www.ijppp.org/1201001A.html.  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectDRNTU::Science::Biological sciences
dc.titleInhibitory effects of salviae miltiorrhizae radix (danshen) and puerariae lobatae radix (gegen) in carbachol-induced rat detrusor smooth muscle contractilityen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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