dc.contributor.authorManavalan, Arulmani
dc.contributor.authorMishra, Manisha
dc.contributor.authorFeng, Lin
dc.contributor.authorSze, Siu Kwan
dc.contributor.authorAkatsu, Hiroyasu
dc.contributor.authorHeese, Klaus
dc.date.accessioned2014-10-10T07:31:58Z
dc.date.available2014-10-10T07:31:58Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationManavalan, A., Mishra, M., Feng, L., Sze, S. K., Akatsu, H., & Heese, K. (2013). Brain site-specific proteome changes in aging-related dementia. Experimental & molecular Medicine, 45(9), e39-.en_US
dc.identifier.issn2092-6413en_US
dc.identifier.urihttp://hdl.handle.net/10220/23994
dc.description.abstractThis study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer’s disease (AD)). Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain site-specific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. Of these proteins, 31 were significantly altered. Most of the differentially regulated proteins are involved in molecular transport, nervous system development, synaptic plasticity and apoptosis. Particularly, proteins such as Gelsolin (GSN), Tenascin-R (TNR) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration. Importantly, our Ingenuity Pathway Analysis (IPA)-based network analysis further revealed ubiquitin C (UBC) as a pivotal protein to interact with diverse AD-associated pathophysiological molecular factors and suggests the reduced ubiquitin proteasome degradation system (UPS) as one of the causative factors of AD.en_US
dc.format.extent17 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesExperimental & molecular medicineen_US
dc.rights© 2013 KSBMB. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.en_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biology
dc.titleBrain site-specific proteome changes in aging-related dementiaen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1038/emm.2013.76
dc.description.versionPublished versionen_US


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