Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96865
Title: Heuristic modeling of macromolecule release from PLGA microspheres
Authors: Paclawski, Adam
Lau, Raymond
Jachowicz, Renata
Mendyk, Aleksander
Szlk, Jakub
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2013
Source: Szlk, J., Paclawski, A., Lau, R., Jachowicz, R., & Mendyk, A. (2013). Heuristic modeling of macromolecule release from PLGA microspheres. International journal of nanomedicine, 8(1), 4601-4611.
Series/Report no.: International journal of nanomedicine
Abstract: Dissolution of protein macromolecules from poly(lactic-co-glycolic acid) (PLGA) particles is a complex process and still not fully understood. As such, there are difficulties in obtaining a predictive model that could be of fundamental significance in design, development, and optimization for medical applications and toxicity evaluation of PLGA-based multiparticulate dosage form. In the present study, two models with comparable goodness of fit were proposed for the prediction of the macromolecule dissolution profile from PLGA micro- and nanoparticles. In both cases, heuristic techniques, such as artificial neural networks (ANNs), feature selection, and genetic programming were employed. Feature selection provided by fscaret package and sensitivity analysis performed by ANNs reduced the original input vector from a total of 300 input variables to 21, 17, 16, and eleven; to achieve a better insight into generalization error, two cut-off points for every method was proposed. The best ANNs model results were obtained by monotone multi-layer perceptron neural network (MON-MLP) networks with a root-mean-square error (RMSE) of 15.4, and the input vector consisted of eleven inputs. The complicated classical equation derived from a database consisting of 17 inputs was able to yield a better generalization error (RMSE) of 14.3. The equation was characterized by four parameters, thus feasible (applicable) to standard nonlinear regression techniques. Heuristic modeling led to the ANN model describing macromolecules release profiles from PLGA microspheres with good predictive efficiency. Moreover genetic programming technique resulted in classical equation with comparable predictability to the ANN model.
URI: https://hdl.handle.net/10356/96865
http://hdl.handle.net/10220/24037
ISSN: 1178-2013
DOI: 10.2147/IJN.S53364
Rights: © 2013 Szlęk et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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