Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/100529
Title: Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells
Authors: Gong, Tianxun
Olivo, Malini
Dinish, U. S.
Goh, Douglas
Kong, Kien Voon
Yong, Ken-Tye
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2013
Source: Gong, T., Olivo, M., Dinish, U. S., Goh, D., Kong, K. V., & Yong, K.-T. (2013). Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. Journal of biomedical nanotechnology, 9(6), 985-991.
Series/Report no.: Journal of biomedical nanotechnology
Abstract: In this paper, we proposed the use of gold nanoparticles as plasmon scattering probes for dark-field multiplex imaging of live cancer cells. By carefully engineering the surfaces, aqueous dispersions of anti-EGFR antibody-conjugated gold nanospheres and gold nanorods are prepared. We demonstrated the receptor-mediated delivery of antibody conjugated gold nanospheres and gold nanorods into EGFR receptor-positive oral squamous cell carcinoma cell line by using dark-field microscopy technique. Our result suggests that gold nanospheres and gold nanorods formulations could provide up to 7 types of plasmon scattering probes based on their tunability range with a 100 nm spectral separation in absorption bands.
URI: https://hdl.handle.net/10356/100529
http://hdl.handle.net/10220/24122
ISSN: 1550-7033
DOI: 10.1166/jbn.2013.1603
Rights: © 2013 American Scientific Publishers.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

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