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|Title:||Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells||Authors:||Gong, Tianxun
Dinish, U. S.
Kong, Kien Voon
|Keywords:||DRNTU::Science::Medicine::Biomedical engineering||Issue Date:||2013||Source:||Gong, T., Olivo, M., Dinish, U. S., Goh, D., Kong, K. V., & Yong, K.-T. (2013). Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. Journal of biomedical nanotechnology, 9(6), 985-991.||Series/Report no.:||Journal of biomedical nanotechnology||Abstract:||In this paper, we proposed the use of gold nanoparticles as plasmon scattering probes for dark-field multiplex imaging of live cancer cells. By carefully engineering the surfaces, aqueous dispersions of anti-EGFR antibody-conjugated gold nanospheres and gold nanorods are prepared. We demonstrated the receptor-mediated delivery of antibody conjugated gold nanospheres and gold nanorods into EGFR receptor-positive oral squamous cell carcinoma cell line by using dark-field microscopy technique. Our result suggests that gold nanospheres and gold nanorods formulations could provide up to 7 types of plasmon scattering probes based on their tunability range with a 100 nm spectral separation in absorption bands.||URI:||https://hdl.handle.net/10356/100529
|ISSN:||1550-7033||DOI:||http://dx.doi.org/10.1166/jbn.2013.1603||Rights:||© 2013 American Scientific Publishers.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||EEE Journal Articles|
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