dc.contributor.authorSong, Shelly Sooyun
dc.contributor.authorKang, Byeong Jun
dc.contributor.authorWen, Lei
dc.contributor.authorLee, Hyo Jin
dc.contributor.authorSim, Hye-ri
dc.contributor.authorKim, Tae Hyong
dc.contributor.authorYoon, Sehyoun
dc.contributor.authorYoon, Bong-June
dc.contributor.authorAugustine, George J.
dc.contributor.authorBaik, Ja-Hyun
dc.date.accessioned2014-11-11T01:46:29Z
dc.date.available2014-11-11T01:46:29Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationSong, S. S., Kang, B. J., Wen, L., Lee, H. J., Sim, H. r., Kim, T. H., et al. (2014). Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. Frontiers in behavioral neuroscience, 8, 1-11.en_US
dc.identifier.issn1662-5153en_US
dc.identifier.urihttp://hdl.handle.net/10220/24219
dc.description.abstractLong-lasting, drug-induced adaptations within the nucleus accumbens (NAc) have been proposed to contribute to drug-mediated addictive behaviors. Here we have used an optogenetic approach to examine the role of NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2Rs) in cocaine-induced behavioral sensitization. Adeno-associated viral vectors encoding channelrhodopsin-2 (ChR2) were delivered into the NAc of D2R-Cre transgenic mice. This allowed us to selectively photostimulate D2R-MSNs in NAc. D2R-MSNs form local inhibitory circuits, because photostimulation of D2R-MSN evoked inhibitory postsynaptic currents (IPSCs) in neighboring MSNs. Photostimulation of NAc D2R-MSN in vivo affected neither the initiation nor the expression of cocaine-induced behavioral sensitization. However, photostimulation during the drug withdrawal period attenuated expression of cocaine-induced behavioral sensitization. These results show that D2R-MSNs of NAc play a key role in withdrawal-induced plasticity and may contribute to relapse after cessation of drug abuse.en_US
dc.format.extent11 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesFrontiers in behavioral neuroscienceen_US
dc.rights© 2014 Song, Kang, Wen, Lee, Sim, Kim, Yoon, Yoon, Augustine and Baik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectDRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
dc.titleOptogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitizationen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicine
dc.identifier.doihttp://dx.doi.org/10.3389/fnbeh.2014.00336
dc.description.versionPublished versionen_US


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