dc.contributor.authorRoser, D. J.
dc.contributor.authorVan Den Akker, B.
dc.contributor.authorBoase, S.
dc.contributor.authorHaas, C. N.
dc.contributor.authorAshbolt, N. J.
dc.contributor.authorRice, S. A.
dc.date.accessioned2014-12-09T03:49:51Z
dc.date.available2014-12-09T03:49:51Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationRoser, D. J., Van Den Akker, B., Boase, S., Haas, C. N., Ashbolt, N. J., & Rice, S. A. Dose–response algorithms for water-borne Pseudomonas aeruginosa folliculitis. Epidemiology and infection,143(7), 1525-1537.en_US
dc.identifier.urihttp://hdl.handle.net/10220/24363
dc.description.abstractWe developed two dose–response algorithms for P. aeruginosa pool folliculitis using bacterial and lesion density estimates, associated with undetectable, significant, and almost certain folliculitis. Literature data were fitted to Furumoto & Mickey's equations, developed for plant epidermis-invading pathogens: N l = A ln(1 + BC) (log-linear model); Pinf = 1−e(−r c C) (exponential model), where A and B are 2.51644 × 107 lesions/m2 and 2.28011 × 10−11 c.f.u./ml P. aeruginosa, respectively; C = pathogen density (c.f.u./ml), N l = folliculitis lesions/m2, Pinf = probability of infection, and r C = 4·3 × 10−7 c.f.u./ml P. aeruginosa. Outbreak data indicates these algorithms apply to exposure durations of 41 ± 25 min. Typical water quality benchmarks (≈10−2 c.f.u./ml) appear conservative but still useful as the literature indicated repeated detection likely implies unstable control barriers and bacterial bloom potential. In future, culture-based outbreak testing should be supplemented with quantitative polymerase chain reaction and organic carbon assays, and quantification of folliculitis aetiology to better understand P. aeruginosa risks.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesEpidemiology and infectionen_US
dc.rights© 2014 Cambridge University Press. This paper was published in Epidemiology and Infection and is made available as an electronic reprint (preprint) with permission of Cambridge University Press. The paper can be found at the following official DOI: [http://dx.doi.org/10.1017/S0950268814002532].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectDRNTU::Engineering::Environmental engineering
dc.subjectDRNTU::Science::Biological sciences
dc.titleDose-response algorithms for water-borne Pseudomonas aeruginosa folliculitisen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1017/S0950268814002532
dc.description.versionPublished versionen_US


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