dc.contributor.authorYeo, Tsin W.
dc.contributor.authorLampah, Daniel A.
dc.contributor.authorKenangelem, Enny
dc.contributor.authorTjitra, Emiliana
dc.contributor.authorWeinberg, J. Brice
dc.contributor.authorGranger, Donald L.
dc.contributor.authorPrice, Ric N.
dc.contributor.authorAnstey, Nicholas M.
dc.date.accessioned2014-12-09T08:37:41Z
dc.date.available2014-12-09T08:37:41Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationYeo, T. W., Lampah, D. A., Kenangalem, E., Tjitra, E., Weinberg, J. B., Granger, D. L., et al. (2014). Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. Journal of infectious diseases, 210(10), 1627-1632.en_US
dc.identifier.urihttp://hdl.handle.net/10220/24404
dc.description.abstractEndothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.en_US
dc.format.extent6 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of infectious diseasesen_US
dc.rights© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@ oup.com.en_US
dc.subjectDRNTU::Science::Biological sciences::Human anatomy and physiology::Human anatomy
dc.titleDecreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malariaen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicine
dc.identifier.doihttp://dx.doi.org/10.1093/infdis/jiu308
dc.description.versionPublished versionen_US


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