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https://hdl.handle.net/10356/103044
Title: | Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids | Authors: | Yang, Peng Xu, Haiyan Zhou, Jianrong Steve |
Keywords: | DRNTU::Science::Chemistry::Physical chemistry::Catalysis | Issue Date: | 2014 | Source: | Yang, P., Xu, H., & Zhou, J. S. (2014). Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids. Angewandte chemie international edition, 53(45), 12210-12213. | Series/Report no.: | Angewandte chemie international edition | Abstract: | The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid derivatives were obtained in good to excellent enantioselectivity. The key toward success was the use of the strongly donating and sterically demanding bisphosphine Binapine. | URI: | https://hdl.handle.net/10356/103044 http://hdl.handle.net/10220/24444 |
ISSN: | 1433-7851 | DOI: | 10.1002/anie.201407744 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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