dc.contributor.authorYuen, Clement
dc.contributor.authorLiu, Quan
dc.date.accessioned2014-12-26T01:04:13Z
dc.date.available2014-12-26T01:04:13Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationYuen, C., & Liu, Q. (2013). Optimization of Fe3O4@Ag nanoshells in magnetic field-enriched surface-enhanced resonance Raman scattering for malaria diagnosis.Analyst, 138(21), 6494-6500.en_US
dc.identifier.urihttp://hdl.handle.net/10220/24529
dc.description.abstractThe great potential of magnetic field enriched surface enhanced resonance Raman spectroscopy (SERRS) for early malaria diagnosis has been demonstrated previously. This technique is able to detect β-hematin, which is equivalent to a malaria biomarker (hemozoin) in Raman features, at a concentration of 5 nM. In this study, we present the optimization of nanoparticles used in the magnetic field enriched SERRS by tuning the core size and shell thickness of nanoparticles with an iron oxide core and a silver shell (Fe3O4@Ag). The discrete dipole approximation (DDA) model was introduced to investigate the localized electromagnetic field distributions and extinction efficiencies of the aggregate of Fe3O4@Ag and β-hematin, in correlation with their magnetic field enriched SERRS performance. We find that the optimal core–shell size of Fe3O4@Ag leading to the effective aggregation of Fe3O4@Ag and β-hematin under an external magnetic field with superior extinction efficiencies is the key to realize highly augmented Raman signals in this strategy. Furthermore, it is noted that the optimized result differs from the case without the external magnetic field to that with the external magnetic field. Therefore, this work demonstrates experimentally and theoretically the potential of tuning the core–shell Fe3O4@Ag for achieving the efficient magnetic field-enriched SERRS detection of β-hematin for early malaria diagnosis.en_US
dc.format.extent7 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAnalysten_US
dc.rightsThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_US
dc.subjectDRNTU::Science::Medicine::Biomedical engineering
dc.titleOptimization of Fe3O4@Ag nanoshells in magnetic field-enriched surface-enhanced resonance Raman scattering for malaria diagnosisen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1039/C3AN00872J
dc.description.versionPublished versionen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record