Chiral bicyclic guanidine-catalysed conjugate addition of α-fluoro-β-ketoesters to cyclic enones
Chin, Kek Foo
Date of Issue2014
School of Physical and Mathematical Sciences
University of Ministry of Education
By utilising a chiral bicyclic guanidine as catalyst and triethylamine as additive, the first asymmetric Michael addition of α-fluoro-β-ketoesters to various cyclic enones has been successfully developed, affording a variety of Michael adducts with potential synthetic utilities with satisfactory stereoselectivity (up to 94 % ee and 4.3 : 1 dr).
Australian journal of chemistry
© 2014 CSIRO. This is the author created version of a work that has been peer reviewed and accepted for publication by Australian Journal of Chemistry, CSIRO. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1071/CH14187].