Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103735
Title: Evaluation of palladacycles as a non-rhodium based alternative for the asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated enones
Authors: Wong, Jonathan
Gan, Kennard
Chen, Houguang Jeremy
Pullarkat, Sumod A.
Keywords: DRNTU::Science::Chemistry::Inorganic chemistry::Synthesis
Issue Date: 2014
Source: Wong, J., Gan, K., Chen, H. J., & Pullarkat, S. A. (2014). Evaluation of palladacycles as a non-rhodium based alternative for the asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated enones. Advanced synthesis & catalysis, 356(16), 3391-3400.
Series/Report no.: Advanced synthesis & catalysis
Abstract: The asymmetric conjugate 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds is an extremely versatile and widely used organic transformation. While the rhodium(I)-catalysed reaction has been thoroughly explored, the asymmetric palladium-catalysed protocol is far less developed and understood, particularly with acyclic enones as substrates. Herein, we report the systematic evaluation of a series of metallacycles for this reaction and the conjugate addition of arylboronic acids to a wide range of α,β-unsaturated enones, catalysed by an easily accessible and robust chiral phosphapalladacycle in high yields and enantioselectivities.
URI: https://hdl.handle.net/10356/103735
http://hdl.handle.net/10220/24564
ISSN: 1615-4150
DOI: http://dx.doi.org/10.1002/adsc.201400473
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
metadata.item.grantfulltext: none
metadata.item.fulltext: No Fulltext
Appears in Collections:SPMS Journal Articles

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