A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
See, Jessica Wei Ting
Zhou, Jianrong Steve
Date of Issue2014
School of Physical and Mathematical Sciences
A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.
Angewandte chemie international edition
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