Palladacycle catalyzed asymmetric P-H addition of diarylphosphines to N-enoyl phthalimides
Chew, Renta Jonathan
Wong, Esther Hui Yen
Pullarkat, Sumod Appukuttan
Date of Issue2014
School of Physical and Mathematical Sciences
The first asymmetric phospha-Michael addition of diarylphosphines to N-enoyl phthalimides has been developed in the presence of a chiral palladacycle catalyst. A library of free chiral tertiary phosphine adducts were directly obtained with excellent yields and enantioselectivities. Products can be subsequently functionalized to afford β-phosphinoamides, the direct preparation of which from cinnamides has been notoriously challenging.
Chemistry - A European journal
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