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|Title:||Molecularly imprinted polymer waveguides for direct optical detection of low-molecular-weight analytes||Authors:||Sharma, Nityanand
|Keywords:||DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding||Issue Date:||2014||Source:||Sharma, N., Petri, C., Jonas, U., Bach, M., Tovar, G., Mrkvová, K., et al. (2014). Molecularly imprinted polymer waveguides for direct optical detection of low-molecular-weight analytes. Macromolecular chemistry and physics, 215(23), 2295-2304.||Series/Report no.:||Macromolecular chemistry and physics||Abstract:||New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a label-free readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photo-crosslinkable poly(N-isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with l-Boc-phenylalanine-anilide (l-BFA, molecular weight 353 g mol−1). Titration experiments with the specific target and other structurally similar reference compounds show good specificity and limit of detection for target l-BFA as low as 2 × 10−6 m.||URI:||https://hdl.handle.net/10356/103606
|ISSN:||1022-1352||DOI:||http://dx.doi.org/10.1002/macp.201400260||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||MSE Journal Articles|
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