A rapid and label-free SERS detection method for biomarkers in clinical biofluids
Kong, Kien Voon
Leong, Weng Kee
Lau, Weber Kam On
Date of Issue2014
School of Physical and Mathematical Sciences
A metal carbonyl-functionalized nanostructured substrate can be used in a rapid and simple assay for the detection of A1AT, a potential biomarker for bladder cancer, in clinical urine samples. The assay involves monitoring changes in the carbonyl stretching vibrations of the metal carbonyl via surface-enhanced Raman spectroscopy (SERS). These vibrations lie in the absorption spectral window of 1800–2200 cm−1, which is free of any spectral interference from biomolecules.
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