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|Title:||Young capillary vessels rejuvenate aged pancreatic islets||Authors:||Almaça, Joana
Arrojo e Drigo, Rafael
Abdulreda, Midhat H.
Jeon, Won Bae
Nam, Hong Gil
|Keywords:||DRNTU::Science::Biological sciences||Issue Date:||2014||Source:||Almaça, J., Molina, J., Arrojo e Drigo, R., Abdulreda, M. H., Jeon, W. B., Berggren, P. O., et al. (2014). Young capillary vessels rejuvenate aged pancreatic islets. Proceedings of the National Academy of Sciences, 111(49), 17612-17617.||Series/Report no.:||Proceedings of the National Academy of Sciences||Abstract:||Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature.||URI:||https://hdl.handle.net/10356/103728
|ISSN:||1091-6490||DOI:||http://dx.doi.org/10.1073/pnas.1414053111||Rights:||© 2014 The Author(s). This paper was published in Proceedings of the National Academy of Sciences and is made available as an electronic reprint (preprint) with permission of the Author(s). The paper can be found at the following official DOI: [http://dx.doi.org/10.1073/pnas.1414053111]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||metadata.item.grantfulltext:||open||metadata.item.fulltext:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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