dc.contributor.authorChoo, Joanna A. L.
dc.contributor.authorThong, Sock Yue
dc.contributor.authorYap, Jiawei
dc.contributor.authorvan Esch, Wim J. E.
dc.contributor.authorRaida, Manfred
dc.contributor.authorMeijers, Rob
dc.contributor.authorLescar, Julien
dc.contributor.authorVerhelst, Steven H. L.
dc.contributor.authorGrotenbreg, Gijsbert M.
dc.date.accessioned2015-01-15T04:26:50Z
dc.date.available2015-01-15T04:26:50Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationChoo, J. A. L., Thong, S. Y., Yap, J., van Esch, W. J. E., Raida, M., Meijers, R., et al. (2014). Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides. Angewandte chemie international edition, 53(49), 13390-13394.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/24627
dc.description.abstractBioorthogonal cleavable linkers are attractive building blocks for compounds that can be manipulated to study biological and cellular processes. Sodium dithionite sensitive azobenzene-containing (Abc) peptides were applied for the temporary stabilization of recombinant MHC complexes, which can then be employed to generate libraries of MHC tetramers after exchange with a novel epitope. This technology represents an important tool for high-throughput studies of disease-specific T cell responses.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte chemie international editionen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Biological sciences
dc.titleBioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptidesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201406295


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