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|Title:||Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides||Authors:||Petersen, Rico
Le Quement, Sebastian T.
Nielsen, Thomas E.
|Keywords:||DRNTU::Science::Chemistry::Organic chemistry::Oxidation||Issue Date:||2014||Source:||Petersen, R., Le Quement, S. T., & Nielsen, T. E. (2014). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. Angewandte chemie international edition, 53(44), 11778-11782.||Series/Report no.:||Angewandte chemie international edition||Abstract:||Massive efforts in molecular library synthesis have strived for the development of synthesis methodology which systematically delivers natural product-like compounds of high spatial complexity. Herein, we present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions. By harnessing the structural side-chain diversity and inherent stereochemical features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochemically diverse compounds was generated, and selected compounds were elaborated into isoform-selective metalloprotease inhibitors.||URI:||https://hdl.handle.net/10356/103931
|ISSN:||1433-7851||DOI:||http://dx.doi.org/10.1002/anie.201405747||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SCELSE Journal Articles|
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