β-functionalization of carboxylic anhydrides with β-alkyl substituents through carbene organocatalysis
Chi, Robin Yonggui
Date of Issue2014
School of Physical and Mathematical Sciences
The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.
Angewandte chemie international edition
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.