Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103846
Title: Injectable, interconnected, high-porosity macroporous biocompatible gelatin scaffolds made by surfactant-free emulsion templating
Authors: Oh, Bernice H. L.
Bismarck, Alexander
Chan-Park, Mary B.
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 2014
Source: Oh, B. H. L., Bismarck, A., & Chan-Park, M. B. (2014). Injectable, interconnected, high-porosity macroporous biocompatible gelatin scaffolds made by surfactant-free emulsion templating. Macromolecular rapid communications, 36(4), 364-372.
Series/Report no.: Macromolecular rapid communications
Abstract: High-porosity interconnected, thermoresponsive macroporous hydrogels are prepared from oil-in-water high internal phase emulsions (HIPEs) stabilized by gelatin-graft-poly(N-isopropylacrylamide). PolyHIPEs are obtained by gelling HIPEs utilizing the thermoresponsiveness of the copolymer components. PolyHIPEs properties can be controlled by varying the aqueous phase composition, internal phase volume ratio, and gelation temperature. PolyHIPEs respond to temperature changes experienced during cell seeding, allowing fibroblasts to spread, proliferate, and penetrate into the scaffold. Encapsulated cells survive ejection of cell-laden hydrogels through a hypodermic needle. This system provides a new strategy for the fabrication of safe injectable biocompatible tissue engineering scaffolds.
URI: https://hdl.handle.net/10356/103846
http://hdl.handle.net/10220/24642
ISSN: 1022-1336
DOI: 10.1002/marc.201400524
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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