dc.contributor.authorBernitt, Erik
dc.contributor.authorKoh, Cheng Gee
dc.contributor.authorGov, Nir
dc.contributor.authorDöbereiner, Hans-Günther
dc.contributor.editorNabi, Ivan R*
dc.identifier.citationBernitt, E., Koh, C. G., Gov, N., & Döbereiner, H.-G. (2015). Dynamics of actin waves on patterned substrates : a quantitative analysis of circular dorsal ruffles. PLOS One, 10(1), e0115857-.en_US
dc.description.abstractCircular Dorsal Ruffles (CDRs) have been known for decades, but the mechanism that organizes these actin waves remains unclear. In this article we systematically analyze the dynamics of CDRs on fibroblasts with respect to characteristics of current models of actin waves. We studied CDRs on heterogeneously shaped cells and on cells that we forced into disk-like morphology. We show that CDRs exhibit phenomena such as periodic cycles of formation, spiral patterns, and mutual wave annihilations that are in accord with an active medium description of CDRs. On cells of controlled morphologies, CDRs exhibit extremely regular patterns of repeated wave formation and propagation, whereas on random-shaped cells the dynamics seem to be dominated by the limited availability of a reactive species. We show that theoretical models of reaction-diffusion type incorporating conserved species capture partially the behavior we observe in our data.en_US
dc.relation.ispartofseriesPLOS Oneen_US
dc.rights© 2015 Bernitt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectDRNTU::Science::Biological sciences
dc.titleDynamics of actin waves on patterned substrates : a quantitative analysis of circular dorsal rufflesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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