Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106744
Title: Palladium catalyzed asymmetric hydrophosphination of α,β- and α,β,γ,δ-unsaturated malonate esters : efficient control of reactivity, stereo- and regio-selectivity
Authors: Leung, Pak-Hing
Yang, Xiang-Yuan
Gan, Jun Hao
Li, Yongxin
Pullarkat, Sumod A.
Keywords: DRNTU::Science::Chemistry::Inorganic chemistry::Metals
Issue Date: 2015
Source: Yang, X.-Y., Gan, J. H., Li, Y., Pullarkat, S. A., & Leung, P.-H. (2015). Palladium catalyzed asymmetric hydrophosphination of α,β- and α,β,γ,δ-unsaturated malonate esters : efficient control of reactivity, stereo- and regio-selectivity. Dalton trans., 44(3), 1258-1263.
Series/Report no.: Dalton transactions
Abstract: Both PC-cyclometalated and PCP-pincer type palladium catalysts have recently been found to be robust and efficacious catalysts for the asymmetric P–H addition reaction involving activated olefins. Our studies on the asymmetric P–H addition of diphenylphosphine to malonate ester and α,β,γ,δ-alkylidenemalonate ester revealed for the first time that the catalyst choice can have a dramatic impact in terms of reactivity as well as regio- and stereo-control for this asymmetric hydrofunctionalization reaction. Besides showing significantly contrasting reactivity and stereoselectivity in the hydrophosphination reaction involving malonate ester, in the case of α,β,γ,δ-alkylidenemalonate ester, a novel regiodivergent method was developed with the 1,4-adduct being obtained exclusively with the PC-catalyst while the pincer catalyst produced only the 1,6-adduct.
URI: https://hdl.handle.net/10356/106744
http://hdl.handle.net/10220/25069
DOI: http://dx.doi.org/10.1039/C4DT02673J
Rights: © 2015 The Author(s) (Published by Royal Society of Chemistry). This is the author created version of a work that has been peer reviewed and accepted for publication by Dalton Transactions, Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C4DT02673J].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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