Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
Seto, Yuan Wah
Date of Issue2015
School of Physical and Mathematical Sciences
A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride.
© 2015 Georg Thieme Verlag Stuttgart · New York. This is the author created version of a work that has been peer reviewed and accepted for publication by Synlett, Georg Thieme Verlag Stuttgart · New York. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1055/s-0034-1379247].