dc.contributor.authorKhosravi, Yalda
dc.contributor.authorSeow, Shih Wee
dc.contributor.authorAmoyo, Arlaine Anne
dc.contributor.authorChiow, Kher Hsin
dc.contributor.authorTan, Tuan Lin
dc.contributor.authorWong, Whye Yen
dc.contributor.authorPoh, Qian Hui
dc.contributor.authorSentosa, Ignatius Mario Doli
dc.contributor.authorBunte, Ralph M.
dc.contributor.authorPettersson, Sven
dc.contributor.authorLoke, Mun Fai
dc.contributor.authorVadivelu, Jamuna
dc.identifier.citationKhosravi, Y., Seow, S. W., Amoyo, A. A., Chiow, K. H., Tan, T. L., Wong, W. Y., et al.. (2015). Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice. Scientific reports, 5.en_US
dc.description.abstractHelicobacter pylori, is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori. Despite H. pylori-infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.en_US
dc.format.extent7 p.en_US
dc.relation.ispartofseriesScientific reportsen_US
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectDRNTU::Science::Biological sciences::Human anatomy and physiology
dc.titleHelicobacter pylori infection can affect energy modulating hormones and body weight in germ free miceen_US
dc.typeJournal Article
dc.contributor.researchSingapore Centre on Environmental Life Sciences Engineering
dc.contributor.schoolLee Kong Chian School of Medicine
dc.description.versionPublished versionen_US

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