dc.contributor.authorZhang, Yuanyuan
dc.contributor.authorQu, Qiuyu
dc.contributor.authorLi, Menghuan
dc.contributor.authorZhao, Yanli
dc.date.accessioned2015-03-24T07:57:42Z
dc.date.available2015-03-24T07:57:42Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationZhang, Y., Qu, Q., Li, M., & Zhao, Y. (2015). Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery. Asian Journal of organic chemistry, 4(3), 226-232.en_US
dc.identifier.issn2193-5807en_US
dc.identifier.urihttp://hdl.handle.net/10220/25270
dc.description.abstractIntracellular, reduction-responsive, amphiphilic, copolymer micelles with cancer cell specificity were developed. The copolymer was prepared with controlled molecular weight and functionalities using a double-headed initiator consisting of a disulfide linkage and folic acid targeting unit. The polymer could self-assemble into spherical micelles, which were stable under physiological conditions. Anticancer drug doxorubicin (DOX) was encapsulated into the micelles during the micellization and then released rapidly into the environment under the stimulus of intracellular reducing agent glutathione. Flow cytometry and confocal laser scanning microscopy observations further indicated that DOX was successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death. The potential of the present copolymer micelles for application as anticancer drug carriers for targeted cancer therapy is promising.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAsian journal of organic chemistryen_US
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistry
dc.titleIntracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug deliveryen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ajoc.201402146


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