dc.contributor.authorXu, Jianfeng
dc.contributor.authorChen, Xingkuan
dc.contributor.authorWang, Ming
dc.contributor.authorZheng, Pengcheng
dc.contributor.authorSong, Bao-An
dc.contributor.authorChi, Robin Yonggui
dc.date.accessioned2015-03-27T07:44:19Z
dc.date.available2015-03-27T07:44:19Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationXu, J., Chen, X., Wang, M., Zheng, P., Song, B. A.,& Chi, Y. R. (2015). Aminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acids. Angewandte chemie International edition, 54(17), 5161-5165.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/25281
dc.description.abstractA convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of azolium enolate intermediate, formaldehyde-derived iminium ion (as an electrophilic reactant), and methanol (as a nucleophilic reactant). This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte chemie International editionen_US
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Chemistry::Physical chemistry::Catalysis
dc.titleAminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acidsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201412132


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