dc.contributor.authorLiu, Albert
dc.contributor.authorJain, Neeraj
dc.contributor.authorVyas, Ajai
dc.contributor.authorLim, Lee Wei
dc.date.accessioned2015-04-06T06:02:20Z
dc.date.available2015-04-06T06:02:20Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationLiu, A., Jain, N., Vyas, A., & Lim, L. W. (2015). Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats. eLife, 2015(4), e04803-.en_US
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttp://hdl.handle.net/10220/25314
dc.description.abstractMemory dysfunction is a key symptom of age-related dementia. Although recent studies have suggested positive effects of electrical stimulation for memory enhancement, its potential targets remain largely unknown. In this study, we hypothesized that spatially targeted deep brain stimulation of ventromedial prefrontal cortex enhanced memory functions in a middle-aged rat model. Our results show that acute stimulation enhanced the short-, but not the long-term memory in the novel-object recognition task. Interestingly, after chronic high-frequency stimulation, both the short- and long-term memories were robustly improved in the novel-object recognition test and Morris water-maze spatial task compared to sham. Our results also demonstrated that chronic ventromedial prefrontal cortex high-frequency stimulation upregulated neurogenesis-associated genes along with enhanced hippocampal cell proliferation. Importantly, these memory behaviors were strongly correlated with the hippocampal neurogenesis. Overall, these findings suggest that chronic ventromedial prefrontal cortex high-frequency stimulation may serve as a novel effective therapeutic target for dementia-related disorders.en_US
dc.format.extent43 p.en_US
dc.language.isoenen_US
dc.relation.ispartofserieseLifeen_US
dc.rights© 2015 The Author(s). This is the author created version of a work that has been peer reviewed and accepted for publication in eLife, published by eLife Sciences Publications on behalf of The Author(s).  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: [http://dx.doi.org/10.7554/eLife.04803].en_US
dc.subjectDRNTU::Science::Biological sciences::Zoology::Anatomy
dc.titleVentromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged ratsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.7554/eLife.04803
dc.description.versionAccepted versionen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record