Reductive cyclization and petasis-like reaction for the synthesis of functionalized γ-lactams
Petersen, Michael Åxman
Cohrt, A. Emil
Clausen, Mads H.
Nielsen, Thomas E.
Date of Issue2015
Singapore Centre on Environmental Life Sciences Engineering
An efficient reductive cyclization strategy was employed for the synthesis of N-substituted β,γ-dihydroxy-γ-lactams. A subsequent Petasis-like reaction (PLR) through nucleophilic additions of boronic acids to intermediate N-acyliminium ions produced substituted γ-lactams. Overall, the application of this protocol provides β,γ-dihydroxy-γ-lactams and functionalized γ-lactams with potential interest for synthetic and bioorganic chemistry.
European journal of organic chemistry
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