dc.contributor.authorTan, Yi Lin Jane
dc.contributor.authorChen, Wei Ning
dc.identifier.citationTan, Y. L. J., & Chen, W. N. (2014). MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects. World journal of gastroenterology, 20(20), 5973-5986.en_US
dc.description.abstractHepatocellular carcinoma (HCC) remains to be one of the top causing cancer-related deaths today. The majority of HCC cases are reported to be the result of chronic hepatitis B virus (HBV) infection. Current treatments for HBV-related HCC revolve around the use of drugs to inhibit viral replication, as a high level of viral load and antigen in circulation often presents a poor patient prognosis. However, existing therapies are inefficient in the complete eradication of HBV, often resulting in tumour recurrence. The involvement of microRNAs (miRNAs) in important processes in HBV-related HCC makes it an important player in the progression of HCC in chronic hepatitis B infected patients. In this review, we discuss the key aspects of HBV infection and the important viral products that may regulate cancer-related processes via their interaction with miRNAs or their closely related protein machinery. Conversely, we also look at how miRNAs may go about regulating the virus, especially in vital processes like viral replication. Apart from miRNAs acting as either oncogenes or tumour-suppressors, we also look at how miRNAs may function as biomarkers that may possibly serve as better candidates than those currently employed in the diagnosis of HBV infection or HBV-related HCC. A summary of the roles of miRNAs in HBV-related HCC will hopefully lead to a gain in understanding of the pathogenesis process and pave the way for new insights in medical therapy.en_US
dc.relation.ispartofseriesWorld journal of gastroenterologyen_US
dc.rights© 2014 Baishideng Publishing. This paper was published in World Journal of Gastroenterology and is made available as an electronic reprint (preprint) with permission of Baishideng Publishing. The paper can be found at the following official DOI: [http://dx.doi.org/10.3748/wjg.v20.i20.5973].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectDRNTU::Science::Biological sciences::Human anatomy and physiology
dc.titleMicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospectsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US

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