Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/93529
Title: Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application
Authors: Lim, Ken Choong
Li, Hao
Liu, Jiayun
Seck, Hon Luen
Yu, Xia
Kok, Shaw Wei
Zhang, Ying
Keywords: DRNTU::Science::Biological sciences::Microbiology
Issue Date: 2015
Source: Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.
Abstract: Two-photon fluorescence (TPE) and second harmonic generation (SHG) can been used to extract biological information from tissues at the molecular level, which is blind to traditional microscopes. Through these two image contrast mechanisms, a nonlinear laser scanning endoscope (NLSE) is able to image tissue cells and the extra cellular matrix (ECM) through a special fiber and miniaturized scanner without the requirement of poisonous chemical staining. Therefore, NLSE reserves high potential for in-vivo pathological study and disease diagnosis. However, the high cost and bulky size of a NLSE system has become one of the major issues preventing this technology from practical clinical operation. In this paper, we report a fiber laser based multi-modality NLSE system with compact size and low cost, ideal for in-vivo applications in clinical environments. The demonstration of the developed NLSE nonlinear imaging capability on different bio-structures in liver, retina and skin are also presented.
URI: https://hdl.handle.net/10356/93529
http://hdl.handle.net/10220/25591
DOI: 10.1117/12.2078809
Rights: © 2015 Society of Photo-optical Instrumentation Engineers. This paper was published in Progress in Biomedical Optics and Imaging - Proceedings of SPIE and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.2078809]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SIMTech Conference Papers

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