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|Title:||Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application||Authors:||Lim, Ken Choong
Seck, Hon Luen
Kok, Shaw Wei
|Keywords:||DRNTU::Science::Biological sciences::Microbiology||Issue Date:||2015||Source:||Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.||Abstract:||Two-photon fluorescence (TPE) and second harmonic generation (SHG) can been used to extract biological information from tissues at the molecular level, which is blind to traditional microscopes. Through these two image contrast mechanisms, a nonlinear laser scanning endoscope (NLSE) is able to image tissue cells and the extra cellular matrix (ECM) through a special fiber and miniaturized scanner without the requirement of poisonous chemical staining. Therefore, NLSE reserves high potential for in-vivo pathological study and disease diagnosis. However, the high cost and bulky size of a NLSE system has become one of the major issues preventing this technology from practical clinical operation. In this paper, we report a fiber laser based multi-modality NLSE system with compact size and low cost, ideal for in-vivo applications in clinical environments. The demonstration of the developed NLSE nonlinear imaging capability on different bio-structures in liver, retina and skin are also presented.||URI:||https://hdl.handle.net/10356/93529
|DOI:||10.1117/12.2078809||Rights:||© 2015 Society of Photo-optical Instrumentation Engineers. This paper was published in Progress in Biomedical Optics and Imaging - Proceedings of SPIE and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.2078809]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SIMTech Conference Papers|
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