Exposure to metals can be therapeutic
Davey, Curtis Alexander
Date of Issue2015
School of Biological Sciences
Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteristics of coordination geometry, redox state and ligand exchange allow one to fine-tune reactivity and affinity properties in a distinct fashion. This intersection of chromatin biology and bioinorganic medicinal chemistry is the subject of multiple collaborations in and between Switzerland and Singapore.
CHIMIA international journal for chemistry
© 2015 Schweizerische Chemische Gesellschaft. This paper was published in CHIMIA International Journal for Chemistry and is made available as an electronic reprint (preprint) with permission of Swiss Chemical Society. The paper can be found at the following official DOI: [http://dx.doi.org/10.2533/chimia.2015.125]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.