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Title: In vivo splenic clearance correlates with In vitro deformability of red blood cells from plasmodium yoelii-infected mice
Authors: Huang, Sha
Amaladoss, Anburaj
Liu, Min
Chen, Huichao
Zhang, Rou
Preiser, Peter R.
Dao, Ming
Han, Jongyoon
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology
Issue Date: 2014
Source: Huang, S., Amaladoss, A., Liu, M., Chen, H., Zhang, R., Preiser, P. R., et al. (2014). In vivo splenic clearance correlates with In vitro deformability of red blood cells from plasmodium yoelii-infected mice. Infection and immunity, 82(6), 2532-2541.
Series/Report no.: Infection and immunity
Abstract: Recent experimental and clinical studies suggest a crucial role of mechanical splenic filtration in the host's defense against malaria parasites. Subtle changes in red blood cell (RBC) deformability, caused by infection or drug treatment, could influence the pathophysiological outcome. However, in vitro deformability measurements have not been directly linked in vivo with the splenic clearance of RBCs. In this study, mice infected with malaria-inducing Plasmodium yoelii revealed that chloroquine treatment could lead to significant alterations to RBC deformability and increase clearance of both infected and uninfected RBCs in vivo. These results have clear implications for the mechanism of human malarial anemia, a severe pathological condition affecting malaria patients.
ISSN: 0019-9567
DOI: 10.1128/IAI.01525-13
Rights: © 2014 American Society for Microbiology. This paper was published in Infection and Immunity and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology. The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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