dc.contributor.authorSusanti, Dewi
dc.contributor.authorLiu, Li-Juan
dc.contributor.authorRao, Weidong
dc.contributor.authorLin, Sheng
dc.contributor.authorMa, Dik-Lung
dc.contributor.authorLeung, Chung-Hang
dc.contributor.authorChan, Philip Wai Hong
dc.date.accessioned2015-06-04T09:02:34Z
dc.date.available2015-06-04T09:02:34Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationSusanti, D., Liu, L.-J., Rao, W., Lin, S., Ma, D.-L., Leung, C. H., et al. (2015). Gold-catalyzed cycloisomerization and diels-alder reaction of 1,4,9-dienyne esters to 3 a,6-methanoisoindole esters with pro-inflammatory cytokine antagonist activity. Chemistry - a European journal, 21(25), 9111-9118.en_US
dc.identifier.issn0947-6539en_US
dc.identifier.urihttp://hdl.handle.net/10220/25763
dc.description.abstractA synthetic method to prepare 3a,6-methanoisoindole esters efficiently by gold(I)-catalyzed tandem 1,2-acyloxy migration/Nazarov cyclization followed by Diels–Alder reaction of 1,4,9-dienyne esters is described. We also report the ability of one example to inhibit binding of tumor necrosis factor-α (TNF-α) to the tumor necrosis factor receptor 1 (TNFR1) site and TNF-α-induced nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation in cell at a half-maximal inhibitory concentration (IC50) value of 6.6 μm. Along with this is a study showing the isoindolyl derivative to exhibit low toxicity toward human hepatocellular liver carcinoma (HepG2) cells and its possible mode of activity based on molecular modeling analysis.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesChemistry - a European journalen_US
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Chemistry::Physical chemistry::Catalysis
dc.titleGold-catalyzed cycloisomerization and diels-alder reaction of 1,4,9-dienyne esters to 3 a,6-methanoisoindole esters with pro-inflammatory cytokine antagonist activityen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/chem.201500795


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