dc.contributor.authorKreisberg, Jason F.
dc.contributor.authorOng, Nicholas T.
dc.contributor.authorKrishna, Aishwarya
dc.contributor.authorJoseph, Thomas L.
dc.contributor.authorWang, Jing
dc.contributor.authorOng, Catherine
dc.contributor.authorOoi, Hui Ann
dc.contributor.authorSung, Julie C.
dc.contributor.authorSiew, Chern Chiang
dc.contributor.authorChang, Grace C.
dc.contributor.authorBiot, Fabrice
dc.contributor.authorCuccui, Jon
dc.contributor.authorWren, Brendan W.
dc.contributor.authorChan, Joey
dc.contributor.authorSivalingam, Suppiah P.
dc.contributor.authorZhang, Lian-Hui
dc.contributor.authorVerma, Chandra
dc.contributor.authorTan, Patrick
dc.date.accessioned2015-06-08T01:03:48Z
dc.date.available2015-06-08T01:03:48Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationKreisberg, J. F., Ong, N. T., Krishna, A., Joseph, T. L., Wang, J., Ong, C., et al. (2013). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy, 57(3), 1513-1517.en_US
dc.identifier.issn0066-4804en_US
dc.identifier.urihttp://hdl.handle.net/10220/25811
dc.description.abstractEmerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAntimicrobial agents and chemotherapyen_US
dc.rights© 2013 American Society for Microbiology (ASM). This paper was published in Antimicrobial Agents and Chemotherapy and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology (ASM). The paper can be found at the following official DOI: [http://dx.doi.org/10.1128/AAC.02327-12]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectDRNTU::Science::Biological sciences::Microbiology::Bacteria
dc.titleGrowth inhibition of pathogenic bacteria by sulfonylurea herbicidesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1128/AAC.02327-12
dc.description.versionPublished versionen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record