Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103475
Title: Adaptation of brain functional and structural networks in aging
Authors: Lee, Annie
Ratnarajah, Nagulan
Tuan, Ta Anh
Chen, Annabel Shen-Hsing
Qiu, Anqi
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
Issue Date: 2015
Source: Lee, A., Ratnarajah, N., Tuan, T. A., Chen, S.-H. A., & Qiu, A. (2015). Adaptation of brain functional and structural networks in aging. PLOS One, 10(4), e0123462-.
Series/Report no.: PLOS One
Abstract: The human brain, especially the prefrontal cortex (PFC), is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI), and high angular resolution diffusion imaging (HARDI), and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging.
URI: https://hdl.handle.net/10356/103475
http://hdl.handle.net/10220/25839
ISSN: 1932-6203
DOI: http://dx.doi.org/10.1371/journal.pone.0123462
Rights: © 2015 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles

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