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Title: Synthesis of (−)-deoxynupharidine by allenic hydroxylamine cyclisation
Authors: Bates, Roderick Wayland
Lim, Chia Juan
Collier, Steven J.
Sukumaran, Joly
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2015
Source: Bates, R. W., Lim, C. J., Collier, S. J., & Sukumaran, J. (2015). Synthesis of (−)-deoxynupharidine by allenic hydroxylamine cyclisation. Asian journal of organic chemistry, 4(7), 652-658.
Series/Report no.: Asian journal of organic chemistry
Abstract: (−)-Deoxynupharidine has been synthesised via an intermediate that can also be used for other Nuphar alkaloids. Significant steps include the optimised enzymatic resolution of an allenic alcohol, highly diastereoselective silver-catalysed cyclisation of an allenic hydroxylamine, selective cross-metathesis, diastereoselective intramolecular reductive amination, and stereoelectronically controlled enolate alkylation.
ISSN: 2193-5807
DOI: 10.1002/ajoc.201500094
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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