Elucidating the role of fat-inducing transmembrane protein 2 (Fit2) in insulin-producing beta-cells (β-cells)
Date of Issue2015
Lee Kong Chian School of Medicine
Fat-Inducing Transmembrane protein 2 (Fit2/Fitm2) is an evolutionarily conserved transmembrane protein. Located on the membrane of the endoplasmic reticulum(ER), Fit2 has been shown to play an important role  in the packaging of triglycerides into lipid droplets(LD) within adipocytes (Fig.1). Pancreatic beta-cells (β-cells) secrete insulin. In diabetes β-cell dysfunction is driven partly by lipid stress (lipotoxicity). Fit2 is expressed in β-cells but its function remains elusive. [2nd Award]
Student Research Poster
© 2015 The Author(s).