Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging
Ramanujan, Raju Vijayaraghavan
Chong, T. W.
Chaughule, R. S.
Patkar, D. P.
Date of Issue2015
School of Materials Science and Engineering
Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe3O4 core to prepare Fe3O4-PNIPAM core–shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core–shell nanostructured samples with different hydrodynamic sizes were prepared. Zeta potential measurements showed that these samples are highly stable in aqueous environment. These core–shell structures were shown to be better contrast agents than conventional Gd chelates for magnetic resonance imaging (MRI). Thus this core–shell Fe3O4-PNIPAM system can be used for multimodal theranostics as a drug carrier, hyperthermia agent and for MRI.
Nanoscience and nanotechnology letters
© 2015 American Scientific Publishers.