dc.contributor.authorCottier, Fabien
dc.contributor.authorTan, Alrina Shin Min
dc.contributor.authorChen, Jinmiao
dc.contributor.authorLum, Josephine
dc.contributor.authorZolezzi, Francesca
dc.contributor.authorPoidinger, Michael
dc.contributor.authorPavelka, Norman
dc.identifier.citationCottier, F., Tan, A. S. M., Chen, J., Lum, J., Zolezzi, F., Poidinger, M., et al. (2015). The transcriptional stress response of candida albicans to weak organic acids. G3 : Genes, Genomes, Genetics, 5(4), 497-505.en_US
dc.description.abstractCandida albicans is the most important fungal pathogen of humans, causing severe infections, especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of the normal human microbiome, where it shares its habitat with hundreds of trillions of other microbial cells. Despite weak organic acids (WOAs) being among the most abundant metabolites produced by bacterial microbiota, little is known about their effect on C. albicans. Here we used a sequencing-based profiling strategy to systematically investigate the transcriptional stress response of C. albicans to lactic, acetic, propionic, and butyric acid at several time points after treatment. Our data reveal a complex transcriptional response, with individual WOAs triggering unique gene expression profiles and with important differences between acute and chronic exposure. Despite these dissimilarities, we found significant overlaps between the gene expression changes induced by each WOA, which led us to uncover a core transcriptional response that was largely unrelated to other previously published C. albicans transcriptional stress responses. Genes commonly up-regulated by WOAs were enriched in several iron transporters, which was associated with an overall decrease in intracellular iron concentrations. Moreover, chronic exposure to any WOA lead to down-regulation of RNA synthesis and ribosome biogenesis genes, which resulted in significant reduction of total RNA levels and of ribosomal RNA in particular. In conclusion, this study suggests that gastrointestinal microbiota might directly influence C. albicans physiology via production of WOAs, with possible implications of how this fungus interacts with its host in both health and disease.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.format.extent9 p.en_US
dc.relation.ispartofseriesG3: Genes, Genomes, Geneticsen_US
dc.rights© 2015 Cottier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectDRNTU::Science::Biological sciences::Genetics
dc.titleThe transcriptional stress response of candida albicans to weak organic acidsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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