Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96686
Title: Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes
Authors: Zhao, Kai
Loh, Teck-Peng
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2014
Source: Zhao, K., & Loh, T.-P. (2014). Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes. Chemistry - A European Journal, 20(50), 16764-16772.
Series/Report no.: Chemistry - A European Journal
Abstract: A highly enantioselective conjugate addition of Grignard reagents to 3-silyl unsaturated esters to deliver synthetically useful chiral β-silylcarbonyl compounds was developed. The synthetic value of this methodology was further illustrated by the synthesis of enantioenriched β-hydroxyl esters and the facile access granted to various α-chiral allylic silanes. A plethora of diastereoselective transformations of β-silylenolates were also investigated and afforded manifold organosilanes that contained contiguous stereogenic centers with excellent enantioselectivity.
URI: https://hdl.handle.net/10356/96686
http://hdl.handle.net/10220/38502
ISSN: 0947-6539
DOI: http://dx.doi.org/10.1002/chem.201403849
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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