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|Title:||Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes||Authors:||Zhao, Kai
|Keywords:||DRNTU::Science::Chemistry::Organic chemistry||Issue Date:||2014||Source:||Zhao, K., & Loh, T.-P. (2014). Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes. Chemistry - A European Journal, 20(50), 16764-16772.||Series/Report no.:||Chemistry - A European Journal||Abstract:||A highly enantioselective conjugate addition of Grignard reagents to 3-silyl unsaturated esters to deliver synthetically useful chiral β-silylcarbonyl compounds was developed. The synthetic value of this methodology was further illustrated by the synthesis of enantioenriched β-hydroxyl esters and the facile access granted to various α-chiral allylic silanes. A plethora of diastereoselective transformations of β-silylenolates were also investigated and afforded manifold organosilanes that contained contiguous stereogenic centers with excellent enantioselectivity.||URI:||https://hdl.handle.net/10356/96686
|ISSN:||0947-6539||DOI:||http://dx.doi.org/10.1002/chem.201403849||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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