Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97885
Title: Cutting edge : synchronization of IRF1, JunB, and C/EBP activities during TLR3-TLR7 cross-talk orchestrates timely cytokine synergy in the proinflammatory response
Authors: Yong, Wai Khang
Sze, Newman Siu Kwan
Tan, Nguan Soon
Liu, Qian
Zhu, Yong
Ding, Jeak Ling
Keywords: DRNTU::Science::Biological sciences::Microbiology::Bacteria
Issue Date: 2015
Source: Liu, Q., Zhu, Y., Yong, W. K., Sze, N. S. K., Tan, N. S., & Ding, J. L. (2015). Cutting edge : synchronization of IRF1, JunB, and C/EBP activities during TLR3-TLR7 cross-talk orchestrates timely cytokine synergy in the proinflammatory response. The Journal of Immunology, 195(3), 801-805.
Series/Report no.: The journal of immunology
Abstract: Multiple pathogen-associated molecular pattern–induced TLR pathway cross-talk provokes proinflammatory cytokine synergy in macrophages, which is important for pathogen resistance and immune homeostasis. However, the detailed mechanisms are unclear. In this article, we demonstrate viral RNA analog–induced transcription synergy of Il6 and Il12b via IFN regulatory factor (IRF)1 (TLR3–TIR domain–containing adaptor inducing IFN-β [TRIF] responsive), C/EBPβ (TLR7-MyD88 responsive), and JunB (all responsive). Coactivation of the TLR3 and TLR7 pathways synchronizes the interaction of IRF1, JunB, and C/EBPβ with the Il6 and Il12b promoters, facilitating maximal gene expression. MyD88 pathway activation suppresses TRIF-induced IRF1 in a delayed manner, controlling the magnitude and timing of cytokine expression. Our findings provide novel mechanisms of cooperation of different TLR pathways to achieve optimal immune responses, with the potential for immunomodulatory strategies.
URI: https://hdl.handle.net/10356/97885
http://hdl.handle.net/10220/38510
DOI: http://dx.doi.org/10.4049/jimmunol.1402358
Rights: © 2015 The American Association of Immunologists.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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