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      A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus

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      A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus.pdf (1.180Mb)
      Author
      Lee, Raphael Tze Chuen
      Gunalan, Vithiagaran
      Van, Thanh Dac
      Le, Ly Thi
      Eisenhaber, Frank
      Maurer-Stroh, Sebastian
      Date of Issue
      2013
      School
      School of Computer Engineering
      School of Biological Sciences
      Version
      Published version
      Abstract
      Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the novel avian-origin H7N9 virus responsible for an outbreak in China. We also show that the internal segments of this precursor strain are closely related to those of the presumed precursor for the HA segment, A/duck/Zhejiang/12/2011(H7N3), which indicates that the sources of both HA and NA donors for the reassortant virus are of regional and not migratory-bird origin and highlights the role of chicken already in the early reassortment events.
      Type
      Journal Article
      Series/Journal Title
      Biology Direct
      Rights
      © 2013 Lee et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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      http://dx.doi.org/10.1186/1745-6150-8-26
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