A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
Author
Lee, Raphael Tze Chuen
Gunalan, Vithiagaran
Van, Thanh Dac
Le, Ly Thi
Eisenhaber, Frank
Maurer-Stroh, Sebastian
Date of Issue
2013School
School of Computer Engineering
School of Biological Sciences
School of Biological Sciences
Version
Published version
Abstract
Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the novel avian-origin H7N9 virus responsible for an outbreak in China. We also show that the internal segments of this precursor strain are closely related to those of the presumed precursor for the HA segment, A/duck/Zhejiang/12/2011(H7N3), which indicates that the sources of both HA and NA donors for the reassortant virus are of regional and not migratory-bird origin and highlights the role of chicken already in the early reassortment events.
Type
Journal Article
Series/Journal Title
Biology Direct
Rights
© 2013 Lee et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Collections
http://dx.doi.org/10.1186/1745-6150-8-26
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