dc.contributor.authorSreejith, Sivaramapanicker
dc.contributor.authorJoseph, James
dc.contributor.authorLin, Manjing
dc.contributor.authorMenon, Nishanth Venugopal
dc.contributor.authorBorah, Parijat
dc.contributor.authorNg, Hao Jun
dc.contributor.authorLoong, Yun Xian
dc.contributor.authorKang, Yuejun
dc.contributor.authorYu, Sidney Wing-Kwong
dc.contributor.authorZhao, Yanli
dc.identifier.citationSreejith, S., Joseph, J., Lin, M., Menon, N. V., Borah, P., Ng, H. J., et al. (2015). Near-infrared squaraine dye encapsulated micelles for in vivo fluorescence and photoacoustic bimodal imaging. ACS Nano, 9(6), 5695-5704.en_US
dc.description.abstractCombined near-infrared (NIR) fluorescence and photoacoustic imaging techniques present promising capabilities for noninvasive visualization of biological structures. Development of bimodal noninvasive optical imaging approaches by combining NIR fluorescence and photoacoustic tomography demands suitable NIR-active exogenous contrast agents. If the aggregation and photobleaching are prevented, squaraine dyes are ideal candidates for fluorescence and photoacoustic imaging. Herein, we report rational selection, preparation, and micelle encapsulation of an NIR-absorbing squaraine dye (D1) for in vivo fluorescence and photoacoustic bimodal imaging. D1 was encapsulated inside micelles constructed from a biocompatible nonionic surfactant (Pluoronic F-127) to obtain D1-encapsulated micelles (D1micelle) in aqueous conditions. The micelle encapsulation retains both the photophysical features and chemical stability of D1. D1micelle exhibits high photostability and low cytotoxicity in biological conditions. Unique properties of D1micelle in the NIR window of 800–900 nm enable the development of a squaraine-based exogenous contrast agent for fluorescence and photoacoustic bimodal imaging above 820 nm. In vivo imaging using D1micelle, as demonstrated by fluorescence and photoacoustic tomography experiments in live mice, shows contrast-enhanced deep tissue imaging capability. The usage of D1micelle proven by preclinical experiments in rodents reveals its excellent applicability for NIR fluorescence and photoacoustic bimodal imaging.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.format.extent10 p.en_US
dc.relation.ispartofseriesACS Nanoen_US
dc.rights© 2015 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Nano, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acsnano.5b02172].en_US
dc.titleNear-infrared squaraine dye encapsulated micelles for in vivo fluorescence and photoacoustic bimodal imagingen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.versionAccepted versionen_US

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