dc.contributor.authorShen, Zhisen
dc.contributor.authorWang, Jian
dc.contributor.authorLu, Dakai
dc.contributor.authorLi, Qun
dc.contributor.authorZhou, Chongchang
dc.contributor.authorZhu, Yabin
dc.contributor.authorHu, Xiao
dc.identifier.citationShen, Z., Wang, J., Lu, D., Li, Q., Zhou, C., Zhu, Y., et al. (2015). Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering. BioMed Research International, 2015, 798721-.en_US
dc.description.abstractBiodegradable polyurethane is an ideal candidate material to fabricate tissue engineered hypopharynx from its good mechanical properties and biodegradability. We thus synthesized a hydrophilic polyurethane via reactions among polyethylene glycol (PEG), e-caprolactone (e-CL) and hexamethylene diisocyanate (HDI), and thrihydroxymethyl propane (TMP). The product possessed a fast degradability due to its good wettability and good mechanical parameters with the elongations at break (137 ± 10%) and tensile strength (4.73 ± 0.46 MPa), which will make it a good matrix material for soft tissue like hypopharynx. Its biological properties were evaluated via in vitro and in vivo tests. The results showed that this hydrophilic polyurethane material can support hypopharyngeal fibroblast growth and owned good degradability and low inflammatory reaction in subcutaneous implantation. It will be proposed as the scaffold for hypopharyngeal tissue engineering research in our future study.en_US
dc.relation.ispartofseriesBioMed Research Internationalen_US
dc.rights© 2015 Zhisen Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleSynthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineeringen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionPublished versionen_US

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